Immunity to influenza in the elderly
Identifieur interne : 000153 ( 1957/Analysis ); précédent : 000152; suivant : 000154Immunity to influenza in the elderly
Auteurs : Robert G. Webster [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2000.
English descriptors
- Teeft :
- Antibody response, Antibody selection, Antigenic, Antigenic drift, Antiviral agents, Available evidence, Cytotoxic activity, Dietary restriction, Elderly individuals, Elderly people, Elderly persons, Elsevier science, Immune, Immune response, Immune responses, Immunological senescence, Point mutations, Possible cause, Proc natl acad, Replicative senescence, Senescence, Surface antigens, Vaccination, Vaccine, Viral immunity, Virus, Webster vaccine.
Abstract
Abstract: Influenza is caused by a constantly varying segmented RNA virus that necessitates yearly review of vaccine composition. Humans over the age of 65 years are considered at high risk from influenza; during influenza epidemics the rate of hospitalization in the elderly is very high and up to 90% mortality can occur. Vaccination of the elderly has been shown to be efficacious and cost effective but immunological senescence in the institutionally confined frail elderly is demonstrated by failure to induce herd immunity after vaccination. Reductions in B- and T-cell immunity and in levels of interleukin-2 are age related. Attempts to increase the immunoresponsiveness of the elderly to influenza vaccines have given mixed results. The most convincing evidence is in rodents where dietary caloric restriction has been shown to enhance viral immunity.
Url:
DOI: 10.1016/S0264-410X(99)00507-1
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001048
- to stream Istex, to step Curation: 001048
- to stream Istex, to step Checkpoint: 000730
- to stream Main, to step Merge: 001958
- to stream Main, to step Curation: 001915
- to stream Main, to step Exploration: 001915
- to stream 1957, to step Extraction: 000153
Links to Exploration step
ISTEX:030437F2B341B548038E5C230B350D363CE5BC1ELe document en format XML
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